Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
FOLFOX is a chemotherapy combination of folinic acid (leucovorin), fluorouracil (5-FU) and oxaliplatin, given by drip every two weeks. It is a standard treatment for bowel cancer, both after surgery and for advanced disease, often with an antibody such as bevacizumab or panitumumab, and is also used for stomach and oesophageal cancers.
For the medicines in FOLFOX, the strongest gene evidence concerns fluorouracil: people with low-function DPYD variants clear it poorly, with a much higher chance of severe side effects, and CPIC and DPWG have published guidelines on DPYD and fluorouracil (see its own page). The studies listed for the regimen itself looked at DPYD and TYMS, fluorouracil's target, for response and side effects.
Every published finding on gene variants and FOLFOX Chemo Regimen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TYMS rs45445694: Level 3. Efficacy: overall survival, Progression-free survival. 13.
TYMS rs11280056: Level 3. Toxicity: Neoplasms. 5.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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