Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
FOLFIRINOX is an intensive chemotherapy combination of folinic acid (leucovorin), fluorouracil (5-FU), irinotecan and oxaliplatin, given by drip every two weeks. It is used mainly for pancreatic cancer, both advanced and after surgery, in people fit enough for its side effects.
Two genes have strong evidence for medicines in FOLFIRINOX. UGT1A1 clears SN-38, the active form of irinotecan, and people with two low-activity copies (such as *28/*28, the Gilbert's syndrome genotype) are more likely to have severe neutropenia and diarrhoea. DPYD breaks down fluorouracil, and people with low-function DPYD variants keep much more of it. Guidelines exist for both genes for the individual medicines, which have their own pages.
Every published finding on gene variants and FOLFIRINOX Chemo Regimen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
UGT1A1 UGT1A1*1, UGT1A1*28: Level 3. Toxicity: Pancreatic Neoplasms, Thrombocytopenia. 1.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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