Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
FEC100 is a chemotherapy combination of fluorouracil (5-FU), epirubicin and cyclophosphamide, given by drip in cycles; the number refers to its higher epirubicin intensity compared with older FEC schedules. It was widely used for early breast cancer after surgery, often followed by a taxane, and has since been partly replaced by other regimens.
For the medicines in FEC100, the strongest gene evidence concerns fluorouracil: people with low-function DPYD variants clear it poorly, with a much higher chance of severe side effects, and guidelines exist for DPYD and fluorouracil (see its own page). The gene studies listed for the regimen itself looked at PPCDC, ALDH1A1 and NQO1 for side effects such as heart damage from epirubicin. These findings are weak.
Every published finding on gene variants and FEC100 Chemo Regimen. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
PPCDC rs147451859: Level 3. Toxicity: Amenorrhea. 1.
rs17587029: Level 3. Toxicity: Amenorrhea. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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