Etanercept (Enbrel)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Etanercept

What it is

Etanercept is a biologic medicine built from the TNF receptor fused to part of an antibody; it acts as a decoy that soaks up TNF, a key signal of inflammation. Injected under the skin once or twice a week, it is used for rheumatoid arthritis, juvenile arthritis, psoriatic arthritis, ankylosing spondylitis and psoriasis. It is sold as Enbrel and as biosimilars.

How genes come into it

Etanercept is not broken down by drug-processing enzymes. The most studied genetic finding is the TNF promoter variant rs1800629 (-308G>A), linked in pooled analyses to a weaker response to TNF blockers in arthritis and psoriasis. Studies have also looked at the TNF receptor genes, CD84 and the antibody receptor FCGR3A. The findings are modest, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Etanercept. Upload your DNA file to see which of these rows apply to you.

Rated evidence (15 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

TNF rs1800629: Level 2B · replicated. Efficacy: Arthritis, Psoriatic, Crohn Disease, Inflammation, Psoriasis, Rheumatoid arthritis, Spondylitis, Ankylosing. 7.

PTPRC rs10919563: Level 3. Efficacy: Rheumatoid arthritis. 2.

CD84 rs6427528: Level 3. Efficacy: Psoriasis, Rheumatoid arthritis. 2.

FCGR3A rs396991: Level 3. Efficacy: Psoriasis. 2.

Response (95 findings)

Studies of how well it worked in people carrying a variant.

rs12081765: Allele G is associated with increased response to adalimumab, certolizumab pegol, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele A.

rs1350948: Allele A is associated with increased response to adalimumab, certolizumab pegol, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele G.

ALPL rs885814: Allele T is associated with decreased response to adalimumab, certolizumab pegol, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele C.

ATP5F1E rs1059150: Genotype GG is associated with decreased response to adalimumab, certolizumab pegol, etanercept, glucocorticoids, infliximab or methotrexate in women with Arthritis, Rheumatoid as compared to genotype TT.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Cimzia (TNF Inhibitors)

Humira (TNF Inhibitors)

Remicade (TNF Inhibitors)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

Back to Medications

Content updated September 2026.

ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.

Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026

Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com