Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Medicines for alcohol dependence support people in stopping or cutting down drinking: acamprosate eases craving after stopping, naltrexone and nalmefene dampen the rewarding effect of alcohol, and disulfiram causes unpleasant reactions to alcohol. They work best combined with counselling. This page collects studies on these medicines as a group.
The gene study listed for the group looked at GATA4, linked in one study to relapse on acamprosate. Gene studies on individual medicines are on their own pages, such as OPRM1 for naltrexone and GRIN2B for acamprosate. The findings are weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Alcohol Dependence Drugs. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GATA4 rs13273672: Level 3. Efficacy: Alcohol abuse. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antabuse (Alcohol Dependence Agents)
Campral (Alcohol Dependence Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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