Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Direct-acting antivirals (DAAs) for hepatitis C block specific viral proteins: NS3/4A protease inhibitors (glecaprevir, voxilaprevir), NS5A inhibitors (ledipasvir, velpatasvir, pibrentasvir) and NS5B polymerase inhibitors (sofosbuvir). Combined in interferon-free tablets such as Epclusa and Mavyret, they cure over 95 in 100 people in 8 to 12 weeks. This page collects studies on DAAs as a group.
The gene studies listed looked at the IFNL3/IFNL4 region, which strongly predicted cure with older interferon treatment; with modern DAA combinations its effect on cure rates is small. Individual DAAs are broken down by different routes, mostly CYP3A4 and transporters. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Direct-Acting Antivirals. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IFNL4 rs11322783: Level 3. Efficacy: Sustained virological response (SVR). 4.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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