Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Daptomycin is a lipopeptide antibiotic that inserts into the membrane of Gram-positive bacteria and disrupts it. Given once daily by drip, it treats complicated skin infections and bloodstream infections, including heart valve infections, caused by Staphylococcus aureus, including MRSA. Muscle damage is a known side effect, so muscle enzymes are checked. It is sold as Cubicin.
Daptomycin is not broken down by liver enzymes; the kidneys clear it largely unchanged. The gene studies listed looked at ABCB1 variants for its blood levels. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Daptomycin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs1045642: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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