Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cyanocobalamin is a manufactured form of vitamin B12, which the body needs to make red blood cells and DNA and to keep nerves healthy. It is used to treat and prevent B12 deficiency, including pernicious anaemia (where the gut cannot absorb B12) and deficiency in people on vegan diets or after stomach surgery, by injection, tablets or nasal spray.
Vitamin B12 works together with folate in the methionine cycle. The single gene study listed looked at MTHFR, whose common variant rs1801133 (C677T) affects homocysteine levels, for how much homocysteine fell with B vitamins. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Cyanocobalamin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MTHFR rs1801131: Level 3. Efficacy: Neoplasms. 4.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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