Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Clavulanic acid (clavulanate) is a beta-lactamase inhibitor: it has little antibacterial effect on its own, but it disables the beta-lactamase enzymes some bacteria use to destroy penicillins. It is combined with amoxicillin (co-amoxiclav, Augmentin) so the antibiotic works against more bacteria, for ear, sinus, chest, skin, dental and bite infections.
Amoxicillin-clavulanate is one of the most common causes of drug-induced liver injury, usually a few weeks after starting, and the clavulanate part is thought to be mainly responsible. Studies have linked immune-system gene versions, such as HLA-DRB1*15:01 and HLA-DQB1*06:02, and HLA-A*02:01 and HLA-B, to a higher risk. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Clavulanate. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HLA-DQB1 rs9274407: Level 3. Toxicity: Drug Toxicity. 1.
HLA-B HLA-B*18:01: Level 3. Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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