Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
CHOP is a chemotherapy combination of cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin) and prednisone, given in three-weekly cycles. With the antibody rituximab added (R-CHOP), it is the standard first treatment for diffuse large B-cell lymphoma and is used for other non-Hodgkin lymphomas.
The few gene studies listed for CHOP looked at CBR3, an enzyme that turns doxorubicin into a breakdown product linked to heart damage, and at the transporter ABCC2, for response and side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline for the regimen or its medicines.
Every published finding on gene variants and CHOP Chemo Regimen. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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