Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Bumetanide is a loop diuretic, about 40 times more potent than furosemide by weight: it blocks salt reabsorption in the loop of Henle, causing a strong increase in urine. It is used to clear fluid build-up in heart failure, kidney disease and liver cirrhosis. It is sold as Bumex and Burinex, among other names.
Bumetanide is cleared partly unchanged by the kidneys and partly by the liver. The gene studies on it, mostly from one study of loop diuretics, looked at genes of salt handling and blood pressure (NPPA-AS1, ADD1, SLC12A3, GNB3, ACE) for how much urine and salt the kidneys passed. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Bumetanide. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC12A3 rs1529927: Level 3. Efficacy. 2.
GNB3 rs5443: Level 3. Efficacy. 1.
NPPA-AS1 rs5063: Level 3. Efficacy. 1.
ADD1 rs4961: Level 3. Efficacy. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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