Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Benazepril is an ACE inhibitor: it blocks angiotensin-converting enzyme, so less angiotensin II is made, blood vessels relax and the body holds less salt. It is used for high blood pressure and, often combined with amlodipine (Lotrel), to lower cardiovascular risk. It is sold as Lotensin, among other names.
Benazepril is a prodrug turned into its active form benazeprilat by liver esterases, not by CYP enzymes. Most gene studies on it, many from China, looked at genes of the renin-angiotensin system (AGT, ACE, AGTR1, CYP11B2) and folate genes (MTHFR, MTR) for how much blood pressure fell. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Benazepril. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ACE rs1799752: Level 3. Efficacy: Diabetes Mellitus. 2.
MTHFR rs1801133: Level 3. Efficacy: Hypertension. 2.
CYP11B2 rs1799998: Level 3. Efficacy: Essential hypertension. 1.
PRCP rs2229437: Level 3. Efficacy: Hypertension. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
ACE Inhibitors (class) (ACE Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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