Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Atezolizumab is an immune checkpoint inhibitor, a monoclonal antibody that blocks PD-L1, a protein tumours use to switch off attacking T cells. Given by drip, it is used for lung cancer (including small cell lung cancer), liver cancer with bevacizumab, bladder cancer and some other cancers. Immune-related side effects can affect many organs. It is sold as Tecentriq.
As an antibody, atezolizumab is not broken down by drug-processing enzymes. The gene study listed looked at IL7, linked in a large study to immune side effects of checkpoint inhibitors. Whether it is used depends on features of the tumour, such as PD-L1 levels, tested on tumour tissue. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Atezolizumab. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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