Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Arsenic compounds used as medicines centre on arsenic trioxide, which, together with all-trans retinoic acid, has made acute promyelocytic leukaemia (APL) one of the most curable leukaemias. It makes the abnormal PML-RARA fusion protein that drives APL break down. It is given by drip and sold as Trisenox. This page collects studies on arsenic compounds as a group.
In the body, arsenic is methylated by the enzyme AS3MT, and people differ in how fast they do this. The few gene studies listed looked at AS3MT and at CBS, a gene of the methionine cycle, for arsenic side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline. Whether arsenic trioxide works depends on the PML-RARA fusion in the leukaemia cells, which is acquired, not inherited.
Every published finding on gene variants and Arsenic Compounds. Upload your DNA file to see which of these rows apply to you.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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