Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Antineoplastic agents are medicines that treat cancer: classic chemotherapy (alkylating agents, antimetabolites, anthracyclines, taxanes, platinum agents and others), targeted medicines that block specific growth signals, hormone therapies and immunotherapies. This page collects studies that looked at cancer medicines as a broad group.
Studies of cancer medicines as a broad group looked at TP53, ABCB1, ABCG2, MTHFR and DPYD, mostly in people treated with several medicines at once. The strongest inherited-gene findings belong to individual medicines and have their own guidelines: DPYD for fluorouracil and capecitabine, TPMT and NUDT15 for the thiopurines, and UGT1A1 for irinotecan. Many targeted medicines depend instead on changes in the tumour, which are not inherited.
Every published finding on gene variants and Antineoplastics. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TP53 rs1042522: Level 3. Toxicity: Drug Toxicity. 5.
DPYD rs1760217: Level 3. Efficacy: Pancreatic Neoplasms. 1.
SERPINA3 rs17091162: Level 3. Efficacy: Pancreatic Neoplasms. 1.
RBFOX1 rs6500843: Level 3. Efficacy: Breast Neoplasms. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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