Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Abiraterone blocks CYP17A1, an enzyme needed to make androgens, so testosterone production falls in the testes, adrenal glands and the tumour itself. It is given with prednisone for advanced prostate cancer, both hormone-sensitive and castration-resistant. It is sold as Zytiga and Yonsa.
Studies have looked at genes of the androgen pathway for how well abiraterone worked: SRD5A2 and HSD3B1 (its 1245C variant, which lets tumours make more potent androgens), CYP17A1, its target, and the transporter SLCO2B1, which carries it into cells. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Abiraterone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
DSE;TSPYL1 rs3828743: Level 3. Efficacy: Prostatic Neoplasms. 1.
SRD5A2 rs523349: Level 3. Efficacy: Prostatic Neoplasms. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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