@keyframes ps-shimmer{0%{background-position:200% 0}to{background-position:-200% 0}}.ps-bg-pattern{position:fixed;top:0;left:0;width:100%;height:100%;z-index:0;pointer-events:none;background-color:var(--ps-bg);background-image:radial-gradient(ellipse 1600px 1200px at 8% 14%,rgba(200,23,63,var(--pg-tint, 0)) 0%,transparent 100%),radial-gradient(ellipse 1500px 1100px at 94% 86%,rgba(200,23,63,calc(var(--pg-tint, 0) * .7)) 0%,transparent 100%),radial-gradient(circle,rgba(200,23,63,.04) 1px,transparent 1px);background-size:100% 100%,100% 100%,30px 30px}.ps-page-wrapper{position:relative;z-index:1;font-family:Inter,system-ui,-apple-system,sans-serif;color:var(--ps-text);line-height:1.6;min-height:100vh;background:var(--ps-bg);padding-top:96px}.ps-container{max-width:1200px;margin:0 auto;padding:0 24px}.ps-leader{background:linear-gradient(135deg,#d42f4f,#ce2346,#c8173f);padding:24px 0 48px;position:relative;overflow:hidden;margin-bottom:28px}.ps-leader:before{content:"";position:absolute;top:-80px;right:-80px;width:400px;height:400px;border-radius:50%;background:radial-gradient(circle,rgba(255,255,255,.08) 0%,transparent 70%);pointer-events:none}.ps-leader:after{content:"";position:absolute;bottom:-60px;left:-60px;width:300px;height:300px;border-radius:50%;background:radial-gradient(circle,rgba(255,255,255,.05) 0%,transparent 70%);pointer-events:none}.ps-leader .ps-container{position:relative;z-index:1}.ps-leader-badge{display:inline-flex;align-items:center;gap:8px;background:#ffffff38;border:1px solid rgba(255,255,255,.3);padding:6px 18px;border-radius:50px;font-size:12px;font-weight:600;color:#fff;margin-bottom:16px}.ps-leader-badge-icon{width:26px;height:26px;background:#fff;border-radius:50%;display:inline-flex;align-items:center;justify-content:center;flex-shrink:0}.ps-leader h1{font-size:36px;font-weight:800;color:#fff;margin:0 0 2px;letter-spacing:-.5px}.ps-leader h1 .ps-h1-short{display:none}.ps-leader .ps-subtitle{color:#ffffffd9;font-size:13px;font-weight:400;margin-bottom:0;max-width:760px;text-wrap:balance}.ps-hero-whatis-row{margin-top:20px}.ps-hero-actionbar{display:inline-flex;align-items:center;gap:18px;flex-wrap:wrap;max-width:100%;margin-top:22px;padding:12px 18px;background:#ffffff24;border:1px solid rgba(255,255,255,.22);border-radius:12px}.ps-hero-actionbar-text{font-size:13.5px;line-height:1.55;color:#ffffffe6;white-space:normal;min-width:0;flex:0 1 auto}.ps-hero-actionbar-text b{color:#fff;font-weight:800}.ps-hero-actionbar.is-locked .ps-hero-actionbar-text b{display:block}.ps-hero-actionbar-sub{display:block;margin-top:4px;font-size:12.5px;line-height:1.5;opacity:.85}.ps-hero-copy{flex-shrink:0;font-family:inherit;font-size:12.5px;font-weight:700;color:var(--ps-brand);background:#fff;border:none;border-radius:8px;padding:9px 18px;cursor:pointer;white-space:nowrap;transition:transform .15s,box-shadow .15s;box-shadow:0 2px 10px #0000001f}.ps-hero-copy:hover{transform:translateY(-1px);box-shadow:0 5px 16px #0000002e}.ps-hero-actionbar.is-locked .ps-hero-copy.is-locked{display:inline-flex;align-items:center;gap:7px;cursor:default;box-shadow:none;background:#9f123917;color:#6b1129b8;border:1px solid rgba(159,18,57,.18)}.ps-hero-actionbar.is-locked .ps-hero-copy.is-locked:hover{transform:none;box-shadow:none}@media(max-width:560px){.ps-hero-copy,.ps-hero-actionbar{width:100%}.ps-hero-actionbar-text{white-space:normal;min-width:0}}.ps-mode-toggle{display:inline-flex;gap:4px;margin-top:22px;background:#ffffff24;border:1px solid rgba(255,255,255,.22);border-radius:12px;padding:4px}.ps-mode-toggle a{display:inline-flex;align-items:center;gap:7px;padding:8px 18px;border:none;background:transparent;color:#fffc;font-size:13.5px;font-weight:700;font-family:inherit;text-decoration:none;border-radius:9px;cursor:pointer;transition:background .18s ease,color .18s ease,box-shadow .18s ease}.ps-mode-toggle a:hover{color:#fff}.ps-mode-toggle a.active{background:#fff;color:var(--ps-brand-dark, #9F1239);box-shadow:0 2px 10px #0000002e}.ps-mode-sub{font-size:10px;font-weight:600;opacity:.6;text-transform:uppercase;letter-spacing:.4px}.ps-whatis-btn{color:var(--ps-text-soft);gap:6px}.ps-whatis-btn .ps-whatis-chev{color:var(--ps-muted);transition:transform .2s ease}.ps-whatis-btn.active{border-color:var(--ps-brand);color:var(--ps-text)}.ps-whatis-btn.active .ps-whatis-chev{transform:rotate(180deg)}.ps-whatis-panel{background:#fff;border:1px solid var(--ps-border);border-radius:10px;padding:16px 20px;margin:-8px 0 22px;max-width:860px;box-shadow:0 2px 8px #c8173f0d;font-size:13px;line-height:1.6;color:var(--ps-text-soft)}.ps-whatis-panel p{margin:0 0 10px}.ps-whatis-panel strong{color:var(--ps-text);font-weight:700}.ps-whatis-panel em{font-style:italic;color:var(--ps-text)}.ps-whatis-h{font-size:11px;font-weight:800;text-transform:uppercase;letter-spacing:.5px;color:var(--ps-brand);margin:14px 0 6px}.ps-whatis-list{margin:0 0 10px;padding-left:18px}.ps-whatis-list li{margin-bottom:6px;line-height:1.55}.ps-whatis-panel a{color:var(--ps-brand);font-weight:600;text-decoration:none}.ps-whatis-panel a:hover{text-decoration:underline}.ps-whatis-refs{font-size:12.5px}.ps-whatis-note{color:var(--ps-muted);font-style:italic;border-top:1px solid var(--ps-border);padding-top:10px;margin-top:12px!important}.ps-explain{background:#fff;border:1px solid var(--ps-border);border-radius:10px;padding:16px 20px;margin-bottom:24px;box-shadow:0 2px 8px #c8173f0d;display:flex;gap:14px;align-items:flex-start}.ps-explain-icon{flex-shrink:0;width:15px;height:15px;margin-top:0}.ps-explain h3{font-size:14px;font-weight:800;color:var(--ps-text);margin:0 0 4px}.ps-explain p{font-size:13px;line-height:1.6;color:var(--ps-text-soft);margin:0}.ps-explain strong{color:var(--ps-text);font-weight:700}.ps-explain-toggle{display:block;width:-moz-fit-content;width:fit-content;max-width:100%;padding:0}.ps-explain-head h3{font-size:12.5px;font-weight:700}.ps-explain-head{width:auto;display:flex;align-items:center;gap:7px;background:none;border:none;cursor:pointer;padding:8px 14px;text-align:left;font-family:inherit}.ps-explain-head h3{flex:0 0 auto;margin:0}.ps-explain-chev{color:var(--ps-muted);flex-shrink:0;margin-left:4px;transition:transform .2s ease}.ps-explain-toggle.open .ps-explain-chev{transform:rotate(180deg)}.ps-explain-body{font-size:13px;line-height:1.6;color:var(--ps-text-soft);margin:0;padding:0 20px 10px 36px;max-width:760px;box-sizing:border-box}.ps-explain-body a{color:var(--ps-brand);font-weight:600;text-decoration:none}.ps-explain-body a:hover{text-decoration:underline}.ps-explain-refs{margin:0;padding:2px 20px 16px 36px;max-width:760px;box-sizing:border-box;font-size:12.5px;color:var(--ps-muted)}.ps-explain-refs a{color:var(--ps-brand);font-weight:600;text-decoration:none}.ps-explain-refs a:hover{text-decoration:underline}.ps-explain-anatomy{margin:0;padding:0 20px 16px 36px;max-width:760px;box-sizing:border-box;font-size:12.5px;color:var(--ps-text-soft)}.ps-explain-anatomy strong{color:var(--ps-text)}.ps-explain-anatomy ul{margin:6px 0 0;padding-left:18px}.ps-explain-anatomy li{margin-bottom:5px;line-height:1.5}.ps-explain-anatomy b{color:var(--ps-text);font-weight:700}.ps-explain em{font-style:italic;color:var(--ps-text)}.ps-explain-btn{display:inline-flex;align-items:center;padding:9px 20px;background:var(--ps-brand);color:#fff;border-radius:8px;font-size:13px;font-weight:700;text-decoration:none;box-shadow:0 2px 8px #c8173f38;transition:transform .15s,box-shadow .15s}.ps-explain-btn:hover{transform:translateY(-1px);box-shadow:0 4px 14px #c8173f4d}.ps-gene-stats{display:flex;gap:14px;margin-top:26px;flex-wrap:wrap;position:relative;top:6px}.ps-gene-stat{background:#ffffff1f;border:1px solid rgba(255,255,255,.18);border-radius:12px;padding:13px 20px;min-width:116px}.ps-gene-stat-num{display:block;font-size:25px;font-weight:800;line-height:1;color:#fff}.ps-gene-stat-num.amber{color:#fcd34d}.ps-gene-stat-num.red{color:#fca5a5}.ps-gene-stat-lbl{display:block;font-size:11.5px;color:#fffc;margin-top:6px}.ps-gene-group-title{display:flex;align-items:center;gap:10px;font-size:16px;font-weight:800;letter-spacing:-.2px;text-transform:none;color:var(--ps-text);margin:0 0 16px}.ps-gene-group-title:before{content:"";width:4px;height:17px;border-radius:2px;flex-shrink:0;background:var(--accent, var(--ps-brand))}.ps-gene-group{margin-bottom:34px}.ps-gene-sub{font-size:10px;color:#ffffffd9;font-weight:600;letter-spacing:.3px;text-transform:uppercase;margin-top:2px}.ps-gene-pheno{display:inline-flex;align-items:center;gap:6px;padding:5px 11px;border-radius:999px;border:1px solid;font-size:11.5px;font-weight:700}.ps-gene-pheno-dot{width:7px;height:7px;border-radius:50%;flex-shrink:0}.ps-gene-diplo-row{display:flex;align-items:center;gap:10px;flex-wrap:wrap;margin-bottom:12px}.ps-gene-diplo-label{font-size:10.5px;color:var(--ps-muted);text-transform:uppercase;letter-spacing:.4px;font-weight:600}.ps-gene-diplo-value{font-family:SF Mono,ui-monospace,Cascadia Code,Menlo,monospace;font-size:14px;font-weight:700;color:var(--ps-text);background:#f1f5f9;padding:3px 9px;border-radius:6px}.ps-gene-activity{font-size:10.5px;font-weight:600;color:var(--ps-text-soft);background:#f8fafc;padding:2px 7px;border-radius:5px;border:1px solid var(--ps-border)}.ps-gene-star-hint{display:inline-flex;align-items:center;gap:4px;font-size:10.5px;font-weight:600;color:var(--ps-brand);background:#fdf2f5;border:1px dashed #F3B6C2;padding:2px 8px;border-radius:999px;cursor:help}.ps-gene-meaning{border:1px solid;border-left-width:3px;border-radius:0 8px 8px 0;padding:9px 12px;margin-bottom:12px}.ps-gene-meaning-title{display:flex;align-items:center;gap:7px;font-size:13px;font-weight:800;line-height:1.35;margin-bottom:3px}.ps-gene-meaning-body{font-size:12.5px;line-height:1.5;opacity:.92}.ps-gene-meaning-dot{width:8px;height:8px;border-radius:50%;flex-shrink:0}.ps-gene-desc{font-size:13px;line-height:1.55;color:var(--ps-text-soft);margin:0 0 12px}.ps-gene-desc-label{font-weight:700;color:var(--ps-text)}.ps-gene-note{font-size:12px;line-height:1.5;color:var(--ps-amber);background:var(--ps-amber-light);border-left:3px solid var(--ps-amber-raw);padding:8px 11px;border-radius:0 6px 6px 0;margin-bottom:12px}.ps-gene-xlinked{display:flex;gap:8px;align-items:flex-start;font-size:12px;line-height:1.5;color:#3730a3;background:#eef2ff;border-left:3px solid #6366F1;padding:8px 11px;border-radius:0 6px 6px 0;margin-bottom:12px}.ps-gene-xlinked svg{flex-shrink:0;margin-top:2px;color:#6366f1}.ps-gene-xlinked strong{color:#312e81}.ps-gene-vars{border-top:1px dashed var(--ps-border);padding-top:10px;margin-bottom:12px}.ps-gene-vars-head{display:flex;align-items:center;gap:8px;width:100%;background:none;border:none;padding:0;cursor:pointer;font-family:inherit;font-size:12px;font-weight:700;color:var(--ps-text-soft);text-align:left}.ps-gene-vars-head:hover{color:var(--ps-text)}.ps-gene-vars-head svg{color:var(--ps-muted);transition:transform .2s ease}.ps-gene-vars-head.open svg{transform:rotate(180deg)}.ps-gene-vars-sub{flex:1;font-size:10px;font-weight:600;color:var(--ps-muted);text-transform:uppercase;letter-spacing:.3px}.ps-gene-vars-list{margin-top:8px;display:flex;flex-direction:column;gap:4px;max-height:240px;overflow-y:auto}.ps-gene-var-row{display:grid;grid-template-columns:1fr 1.2fr auto;gap:8px;align-items:center;font-family:SF Mono,ui-monospace,Menlo,monospace;font-size:11.5px;background:#fff7f9;border:1px solid #FBD5DF;border-radius:6px;padding:5px 9px}.ps-gene-var-rsid{color:var(--ps-brand);font-weight:600}.ps-gene-var-pos{color:var(--ps-text-soft)}.ps-gene-var-call{color:var(--ps-text);font-weight:700;justify-self:end}.ps-gene-var-row.isref{background:#f8fafc;border-color:var(--ps-border)}.ps-gene-var-row.isref .ps-gene-var-rsid{color:var(--ps-muted);font-weight:500}.ps-gene-var-row.isref .ps-gene-var-call{color:var(--ps-text-soft);font-weight:600}.ps-gene-drugs{border-top:1px dashed var(--ps-border);padding-top:12px}.ps-gene-drugs-head{font-size:12px;font-weight:700;color:var(--ps-text);margin-bottom:10px;display:flex;align-items:center;gap:8px;flex-wrap:wrap}.ps-gene-drugs-action{font-size:10px;font-weight:700;color:var(--ps-danger);background:var(--ps-danger-light);border:1px solid #FECACA;padding:2px 8px;border-radius:999px;text-transform:uppercase;letter-spacing:.3px}.ps-gene-chips{display:flex;flex-wrap:wrap;gap:7px;position:relative}.ps-gene-chip{display:inline-flex;align-items:center;gap:5px;font-size:12px;font-weight:600;color:var(--ps-text-soft);text-decoration:none;background:#f1f5f9;border:1px solid var(--ps-border);padding:4px 10px;border-radius:7px;transition:background .15s,color .15s}.ps-gene-chip:hover{background:#e2e8f0;color:var(--ps-text)}.ps-gene-chip-action{background:var(--ps-danger-light);border-color:#fecaca;color:var(--ps-danger)}.ps-gene-chip-action:hover{background:#fee2e2}.ps-gene-chip-star{font-size:7px;color:var(--ps-danger-dark)}.ps-gene-more{font-size:12px;font-weight:600;color:var(--ps-text-soft);background:none;border:1px dashed var(--ps-border);padding:4px 10px;border-radius:7px;cursor:pointer}.ps-gene-more:hover{background:#f8fafc}.ps-gene-empty{text-align:center;color:var(--ps-muted);font-size:14px;padding:50px 0}.ps-gene-nodrugs{font-size:12.5px;color:var(--ps-muted);font-style:italic}.ps-gene-guidance-info{display:inline-flex;align-items:center;color:var(--ps-muted);cursor:help}.ps-gene-guidance-info:hover{color:var(--ps-brand)}.ps-pgx-actionbar{display:flex;align-items:center;justify-content:space-between;gap:16px;flex-wrap:wrap;background:#fff;border:1px solid var(--ps-border);border-radius:12px;padding:14px 18px;margin-bottom:22px;box-shadow:0 4px 16px #c8173f0f}.ps-pgx-actionbar-text{font-size:13.5px;color:var(--ps-text-soft);line-height:1.5}.ps-pgx-actionbar-text b{color:var(--ps-text);font-weight:800}.ps-pgx-copy{flex-shrink:0;font-size:12.5px;font-weight:700;font-family:inherit;color:#fff;background:var(--ps-brand);border:none;border-radius:8px;padding:9px 18px;cursor:pointer;transition:transform .15s,box-shadow .15s,background .15s;box-shadow:0 2px 8px #c8173f38}.ps-pgx-copy:hover{transform:translateY(-1px);box-shadow:0 4px 14px #c8173f4d}.ps-pgx-allclear{background:var(--ps-success-light);border:1px solid #BBF7D0;color:#166534;border-radius:12px;padding:18px 20px;font-size:14px;font-weight:600}.ps-pgx-normal-head{display:flex;align-items:center;gap:10px;width:100%;background:#fff;border:1px solid var(--ps-border);border-radius:12px;padding:13px 16px;cursor:pointer;font-family:inherit;font-size:13.5px;color:var(--ps-text-soft);text-align:left;transition:border-color .15s}.ps-pgx-normal-head:hover{border-color:#bbf7d0}.ps-pgx-normal-head.uncertain:hover{border-color:#cbd5e1}.ps-pgx-normal-head.uncertain .ps-pgx-normal-dot{background:#94a3b8}.ps-pgx-normal-head b{color:var(--ps-text);font-weight:700}.ps-pgx-normal-head>span:nth-child(2){flex:1}.ps-pgx-normal-dot{width:9px;height:9px;border-radius:50%;background:var(--ps-success);flex-shrink:0}.ps-pgx-normal-chev{color:var(--ps-muted);flex-shrink:0;transition:transform .2s ease}.ps-pgx-normal-head.open .ps-pgx-normal-chev{transform:rotate(180deg)}.ps-pgx-normal-chips{display:flex;flex-wrap:wrap;gap:7px;margin-top:12px}.ps-pgx-normal-chip{font-size:12px;font-weight:600;color:var(--ps-text-soft);background:#fff;border:1px solid var(--ps-border);border-radius:7px;padding:4px 10px;font-family:SF 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.2s;overflow:visible;position:relative}.ps-profile-card:hover{transform:translateY(-3px);box-shadow:0 8px 32px #00000024,0 2px 6px #00000014}.ps-profile-info-icon{position:absolute;top:16px;right:14px;display:flex;align-items:center;gap:8px}.ps-profile-pie{position:relative;width:36px;height:36px;border-radius:50%;cursor:help}.ps-profile-bars{position:relative;display:flex;align-items:flex-end;justify-content:flex-end;gap:5px;height:40px;cursor:help}.ps-profile-bar-col{display:flex;flex-direction:column;align-items:center;justify-content:flex-end;gap:2px}.ps-profile-bar-num{font-size:9px;font-weight:800;line-height:1}.ps-profile-bar{width:9px;min-height:4px;border-radius:3px 3px 0 0}.ps-profile-pie-hole{width:20px;height:20px;border-radius:50%;background:#fff;position:absolute;top:8px;left:8px;display:flex;align-items:center;justify-content:center}.ps-profile-tooltip{display:none;position:absolute;bottom:calc(100% + 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span{font-size:10px;font-weight:700}.ps-toolbar{display:flex;align-items:center;gap:12px;margin-bottom:20px;padding-top:10px;flex-wrap:wrap;position:relative;z-index:2}.ps-toolbar.ps-category-toolbar{padding-top:0;margin-top:-12px}.ps-filter-toolbar{gap:8px}.ps-filter-toolbar .ps-filter-btn{padding:8px 10px;gap:4px}.ps-filter-toolbar .ps-filter-count{font-size:.75em}.ps-search-box{flex:1;min-width:200px;position:relative}.ps-search-box.ps-search-narrow{flex:1 1 380px;min-width:220px}.ps-search-box input{width:100%;padding:10px 14px;border:1px solid var(--ps-border);border-radius:10px;font-size:13px;font-family:inherit;background:#fff;transition:border-color .2s}.ps-search-box input:focus{outline:none;border-color:var(--ps-brand)}.ps-filter-btn{padding:8px 16px;border-radius:10px;border:1px solid var(--ps-border);background:#fff;font-size:12px;font-weight:600;font-family:inherit;cursor:pointer;transition:all 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